Penrose's 'quasi-local mass and angular momentum' (Penrose, Proc. R. Soc. Lond. A 381, 53 (1982)) is investigated for 2-surfaces near spatial infinity in both linearized theory on Minkowski space and full general relativity. It is shown that for space-times that are radially smooth of order one in the sense of Beig & Schmidt (Communs math. Phys. 87, 65 (1982)), with asymptotically electric Weyl curvature, there exists a global concept of a twistor space at spatial infinity. Global conservation laws for the energy-momentum and angular momentum are obtained, and the ten conserved quantities are shown to be invariant under asymptotic coordinate transformations. The relation to other definitions is discussed briefly.